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pentobarbital will lower the extent or impact of gefitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the extent or impact of cinacalcet by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.Induction of microsomal enzymes by this drug, may well shorten the half-lifetime of doxycyc